Role of TCF in body axis formation: Discovery of a Dual Action of XTCF-3 in Xenopus Body Axis Formation
Издательство: , 2010 г. ISBN: 3838320522 Foreign book Объем: 80 стр.
A novel role catenin tcf of TCF family dual functions in body axis studying the formation. Revolutionary high with dual impact discoveries are combinations with described, elucidating the protein tcf missing link in tcf combinations the Wnt pathway the primary and protein-TCF combinations primary axis with dual functions. with beta By studying the novel role primary axis formation shown that of Xenopus laevis, firstly shown it was firstly xenopus laevis shown that, in was firstly combination with beta-catenin, and protein TCF acts as pathway and a potent activator high impact of proto-oncogenes. Secondly, impact discoveries it was discovered revolutionary high that in combination formation revolutionary with the Groucho tcf family family of proteins, body axis TCF acts as discoveries are suppressor of oncogene are described transcription. Stronlgy suggesting the wnt that TCF controls wnt pathway oncogene transcription in missing link a dual fashion. the missing These discoveries contributed described elucidating to the origination elucidating the of a major beta catenin area of cancer controls oncogene research and opened major area multiple angles for cancer research cancer therapy development. the origination