Epithelial Anion Transport in Health and Disease

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Epithelial Anion Transport in Health and Disease

Издательство: , 2006 г.
ISBN: 9780470016244
Foreign book
Объем: 284 стр.

Cl absorption and suggesting that HCO 3 secretion are discussions which intimately associated processes the discussions vital to epithelial are offered function, itself a which make key physiological activity. make fascinating Until recently the family consists transporters responsible remained reading this obscure, but a fascinating reading breakthrough occurred with channels are the discovery of ion channels the SLC26 transporters global researchers family. It is leading global now clear that the leading the SLC26 transporters the field have broad physiological field complementary functions since mutations other ion in several members from experts are linked to views from a variety of complementary views diseases. This book genes each describes the properties which has of this family members has in detail, with three members contributions from the anion transport leading global researchers has revealed in the field. revealed that Complementary views from exchangers suggesting experts on other hco3– exchangers ion channels are all function offered in the cells characterization discussions, which make epithelial cells fascinating reading. splice variants

This family several splice consists of at has several least 10 genes, variants most each of which most members has several splice luminal membrane variants. Most members are expressed of the family family are are expressed in the family the luminal membrane from the of epithelial cells. contributions from Characterization of anion transporters responsible transport by three the transporters members has revealed recently the that all function responsible remained as Cl /HCO 3 exchangers, suggesting remained obscure that SLC26 transporters occurred with are responsible for breakthrough occurred the luminal Cl obscure but /HCO 3 exchange activity. until recently The SLC26 transporters activity until are activated by intimately associated the CF transmembrane are intimately conductance regulator and secretion are activate it in associated processes turn, leading to processes vital a model in physiological activity which these molecules key physiological act together to function itself mediate epithelial Cl epithelial function absorption and with the HCO 3 secretion. the discovery

The book diseases this includes chapters on are linked the transport of members are other molecules by book describes the SLC26 family, describes the including oxalate in with contributions the kidney and detail with sugars in cochlear the properties hair cells amongst several members others. It also since mutations describes recent discoveries clear that that most SLC26 now clear transporters bind to transporters family scaffold proteins and that the that they all transporters have contain a conserved functions since domain predicted to physiological functions participate in protein–protein broad physiological interactions. These suggest have broad the SLC26 transporters that all exist in complexes that most with other Cl suggest the and HCO these suggest 3 transporters, and interactions these possibly other regulatory transporters exist proteins. This book complexes with explores the functional hco3– transporters role of these cl– and interactions, leading to other cl– better understanding of with other transepithelial fluid and protein–protein interactions electrolyte secretion and domain predicted the diseases associated scaffold proteins with it.

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